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Drug Interaction In Palliative Care
Interaction of drugs in palliative care is one of the most important topics in the area of medical research. It is often occurs due to Polytherapy. Polytherapy is the kind of treatment given to patients with advance disease. In this case, a patient is being treated with more than one drug which results in unfavorable interactions, both pharmacokinetic and pharmacodynamics. This results in the development of new symptoms and distinguishing the new symptom from the disease is an essential factor in evaluating the patient’s status. |
Non-steroidal anti inflammatory drugs develop unfavorable interaction with the drugs used for the treatment of cardiovascular diseases and this reduces its effectiveness of use. They interact with blood proteins and cause undesirable effects. It also causes gastrointestinal related problems and other side effects which are the common factor that limits its use.
Codeine, given along with hypnotics, tricyclic antidepressants and neuroleptic drugs often gives depressive influence on the central nervous system. Tramadol causes seizures when administered with neuroleptics. It has a high risk of causing hypotension with hypotensive drugs. Tramadol side effect can be reduced by starting with a low dose and increasing gradually. Nefopam causes hyperthermia and severe hypertension if used along with tricyclic antidepressants.
Some antidepressant drugs used in pain pharmacotherapy also causes unfavorable interactions when administered with other drugs. Metamizole when used with neuroleptics and phenothiazine derivative causes severe hyperthermia. Paracetamol should be coadministered very cautiously with drugs that inhibit the activity of isoenzyme. Paracetamol increases kidney’s elimination of prostaglandins and decreases plasma rennin activity. The appropriate Polytherapy by avoiding unfavorable drugs and post drug interaction is more important for pharmacotherapy in palliative medicine.
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Drug Interaction In Palliative Care
